Acculturation refers to the process through which a person from one culture adopts the values, culture, and practices of another culture, while still retaining their own heritage culture. Acculturation has important implications on Latinos’ health and well-being, including smoking. Acculturation measures such as country of origin, language, gender, and years living in the U.S. account for part of the variability in Latino smoking patterns. Interestingly, acculturation and smoking behavior show an inverse relationship by gender among Latinos. Acculturation is associated with increased smoking for women and a decrease in smoking for men. In fact, greater acculturation predicts higher abstinence rates for men but not for women (Figure 1).